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The effects of anemias and coagulation disorders on conception

Stefania Holdunu
Stefania Holdunu
Medicine Doctor
Written on

The effects of anemias and coagulation disorders on conception are diverse and can significantly impact women’s reproductive health.

Anemia is a complex disorder characterized by low levels of hemoglobin or red blood cells, resulting in a reduced capacity to transport oxygen to organs and tissues. The effects of these conditions on conception can vary considerably depending on the type and severity of the anemia.

Fanconi Anemia (FA), although a rare condition, represents the most common form of inherited bone marrow failure syndrome. It manifests with skeletal anomalies, short stature, and aplastic anemia. The prevalence of FA varies among different ethnic groups, with an incidence of approximately 1 case per 360,000 newborns. This condition can affect bone marrow function, including the production of reproductive cells, sometimes leading to conception difficulties or infertility.

Diamond-Blackfan Anemia (DBA) is another rare condition characterized by deficiencies in red blood cell production. Its incidence is estimated at around 5-7 cases per 1 million live births, though exact data may be underestimated due to the rarity of this condition. Its direct effects on conception are still under investigation, but severe anemia, in general, can influence the reproductive system, potentially affecting menstrual cycles and fertility.

Deficiencies in iron, vitamin B12, or other essential nutrients can also influence the capacity for conception. Lack of these vital nutrients can negatively impact ovulation and the normal function of the uterus, increasing the difficulty of becoming pregnant or raising the risk of miscarriage.

Von Willebrand Disease, a blood coagulation disorder, is often associated with heavy menstrual bleeding and may create complications during pregnancy, including an increased risk of miscarriage or childbirth complications.

These anemias can affect not only menstruation and ovulation but also overall fertility. Treatment and correction of nutritional deficiencies can play a crucial role in improving reproductive health. Consulting a doctor for a personalized treatment plan, which may include supplements and specific interventions, is essential for managing anemias before and during pregnancy.

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